n-acetylleucine to 8-methoxykynurenate

Numerator Metabolite

Structure of n-acetylleucine
Metabolite Accession: GCST90200288
Name: n-acetylleucine
Hmdb Id: HMDB0011756
Super Pathway: NA
Sub Pathway: NA
Inchikey: WXNXCEHXYPACJF

Denominator Metabolite

Structure of 8-methoxykynurenate
Metabolite Accession: GCST90200186
Name: 8-methoxykynurenate
Hmdb Id: HMDB0060426
Super Pathway: NA
Sub Pathway: NA
Inchikey: BXZSKDOPGDPDEG

Associated Genomic Regions

Region: rs1177442

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.185
Position:
25809069
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
-8.578
Reference Allele:
G
-log10(P):
-39.182
MAF:
0.444
Beta (Num):
-0.090
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.095
SE (Den):
0.017
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Leucine metabolism.3[1]

Denominator Metabolite Explanation:

Tryptophan metabolism.4[1], 5[2]

Ratio Explanation:

The ratio may reflect altered transport by SLC17A4, affecting the balance of unrelated amino acid-derived metabolites, n-acetylleucine and 8-methoxykynurenate.

Ratio Evidence:

metabolites unrelated

Gene Ratio Phenotype Relationship:

The SLC17A4 missense variant likely alters uric acid transport, impacting serum uric acid and related hematological traits like MCHC and MCH.2[1], 6[2], 7[3] The link to n-acetylleucine and 8-methoxykynurenate is not established.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data