methyl indole-3-acetate to indoleacetylglutamine

Numerator Metabolite

Structure of methyl indole-3-acetate
Metabolite Accession: GCST90200296
Name: methyl indole-3-acetate
Hmdb Id: HMDB0029738
Super Pathway: NA
Sub Pathway: NA
Inchikey: KTHADMDGDNYQRX

Denominator Metabolite

Structure of indoleacetylglutamine
Metabolite Accession: GCST90199817
Name: indoleacetylglutamine
Hmdb Id: HMDB0013240
Super Pathway: NA
Sub Pathway: NA
Inchikey: DVJIJAYHBZALOJ

Associated Genomic Regions

Region: rs2271060

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
16
Beta (Ratio):
-0.281
Position:
20482623
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
-14.158
Reference Allele:
G
-log10(P):
-103.104
MAF:
0.277
Beta (Num):
-0.063
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.218
SE (Den):
0.019
No CNV overlap
rQTL cluster:
31
Reaction Distance:
NA
Closest Genes:
ACSM2A AC137056.1 ACSM5 ACSM2B PDILT

LLM Analysis

Numerator Metabolite Explanation:

Tryptophan metabolism4[1]

Denominator Metabolite Explanation:

Tryptophan metabolism5[1], 6[2], 7[3]

Ratio Explanation:

This ratio reflects the balance between methylation and glutamine conjugation of indole-3-acetate, a key molecule in tryptophan metabolism.5[1], 6[2], 7[3], 8[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No direct ratio-phenotype link is provided. The associated gene, THEM4, is involved in diverse cellular processes including lipid metabolism and apoptosis.1[1], 3[2], 9[3]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data