oleoyl ethanolamide to Docosahexaenoate DHA; 22:6n3

Numerator Metabolite

Structure of oleoyl ethanolamide
Metabolite Accession: GCST90200299
Name: oleoyl ethanolamide
Hmdb Id: HMDB0002088
Super Pathway: NA
Sub Pathway: NA
Inchikey: BOWVQLFMWHZBEF

Denominator Metabolite

Structure of docosahexaenoate (dha; 22:6n3)
Metabolite Accession: GCST90199651
Name: docosahexaenoate (dha; 22:6n3)
Hmdb Id: HMDB0002183
Super Pathway: NA
Sub Pathway: NA
Inchikey: MBMBGCFOFBJSGT

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.274
Position:
46870761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
15.850
Reference Allele:
C
-log10(P):
-128.604
MAF:
0.209
Beta (Num):
0.267
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.008
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
10.0
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Endocannabinoid/N-acylethanolamine metabolism.3[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid metabolism/Omega-3 fatty acid pathway.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio reflects FAAH activity; decreased function leads to higher oleoyl ethanolamide (numerator), while DHA (denominator), not a direct FAAH substrate, remains unaffected by FAAH.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype was provided in the input data. Therefore, a link between the genetic factor, metabolite ratio, and a potential phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data