oleoyl ethanolamide to adrenate (22:4n6)

Numerator Metabolite

Structure of oleoyl ethanolamide
Metabolite Accession: GCST90200299
Name: oleoyl ethanolamide
Hmdb Id: HMDB0002088
Super Pathway: NA
Sub Pathway: NA
Inchikey: BOWVQLFMWHZBEF

Denominator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.290
Position:
46870761
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
18.561
Reference Allele:
C
-log10(P):
-175.410
MAF:
0.209
Beta (Num):
0.267
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.024
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs174536

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.204
Position:
61551927
SE (Ratio):
0.013
Effect Allele:
C
Z-score (Ratio):
15.145
Reference Allele:
A
-log10(P):
-117.633
MAF:
0.342
Beta (Num):
0.026
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.178
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Endocannabinoid signaling8[1], 9[2], 10[3]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid (PUFA) biosynthesis11[1], 12[2]

Ratio Explanation:

The ratio reflects the balance between oleoyl ethanolamide degradation by FAAH and adrenate synthesis, influenced by FADS1/FADS2 activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The FAAH missense variant reduces its protein stability, increasing oleoyl ethanolamide levels.2[1], 3[2], 13[3] This alteration in endocannabinoid signaling, combined with FADS1/FADS2 mediated PUFA metabolism, may influence lipid-related disorders and inflammatory conditions like follicular cysts, potentially through shared inflammatory or metabolic pathways.14[4], 15[5], 16[6]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data