oleoyl ethanolamide to docosatrienoate (22:3n3)

Numerator Metabolite

Structure of oleoyl ethanolamide
Metabolite Accession: GCST90200299
Name: oleoyl ethanolamide
Hmdb Id: HMDB0002088
Super Pathway: NA
Sub Pathway: NA
Inchikey: BOWVQLFMWHZBEF

Denominator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs968567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.279
Position:
61595564
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
-14.536
Reference Allele:
C
-log10(P):
-108.555
MAF:
0.179
Beta (Num):
-0.001
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.278
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Endocannabinoid/N-acylethanolamine metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid (PUFA) metabolism.7[1]

Ratio Explanation:

The ratio of oleoyl ethanolamide to docosatrienoate reflects the balance between omega-9 and omega-3 fatty acid metabolism, which is influenced by FADS1/FADS2 activity.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid metabolism, impacting the balance of pro- and anti-inflammatory mediators.8[1], 9[2], 10[3] This inflammatory dysregulation may predispose individuals to conditions like dermatitis, asthma, and sinusitis, and also affects blood lipid profiles.1[4], 11[5], 12[6], 13[7], 14[8], 15[9], 16[10]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data