oleoyl ethanolamide to docosapentaenoate n3 DPA; 22:5n3

Numerator Metabolite

Structure of oleoyl ethanolamide
Metabolite Accession: GCST90200299
Name: oleoyl ethanolamide
Hmdb Id: HMDB0002088
Super Pathway: NA
Sub Pathway: NA
Inchikey: BOWVQLFMWHZBEF

Denominator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.285
Position:
46870761
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
18.681
Reference Allele:
C
-log10(P):
-177.654
MAF:
0.209
Beta (Num):
0.267
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.018
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs174536

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.165
Position:
61551927
SE (Ratio):
0.013
Effect Allele:
C
Z-score (Ratio):
12.555
Reference Allele:
A
-log10(P):
-81.581
MAF:
0.342
Beta (Num):
0.026
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.139
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Numerator Pathway(s): N-acylethanolamine biosynthesis, Endocannabinoid signaling.9[1], 10[2], 11[3]

Denominator Metabolite Explanation:

Denominator Pathway(s): Omega-3 fatty acid metabolism, PUFA biosynthesis.12[1], 13[2], 14[3]

Ratio Explanation:

Ratio Interpretation: This ratio reflects the balance between endocannabinoid degradation (numerator) and omega-3 fatty acid synthesis (denominator), both influenced by the associated genes FAAH and FADS.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Ratio-Phenotype Link: Variants in *FADS1* and *FADS2* alter polyunsaturated fatty acid metabolism, affecting levels of lipids like cholesterol and triglycerides.7[1], 15[2] This altered lipid profile is strongly associated with the observed phenotypes of hypercholesterolemia, cholelithiasis, and other disorders of lipoprotein metabolism.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data