oleoyl ethanolamide to 2-hydroxypalmitate

Numerator Metabolite

Structure of oleoyl ethanolamide
Metabolite Accession: GCST90200299
Name: oleoyl ethanolamide
Hmdb Id: HMDB0002088
Super Pathway: NA
Sub Pathway: NA
Inchikey: BOWVQLFMWHZBEF

Denominator Metabolite

Structure of 2-hydroxypalmitate
Metabolite Accession: GCST90199795
Name: 2-hydroxypalmitate
Hmdb Id: HMDB0031057
Super Pathway: NA
Sub Pathway: NA
Inchikey: JGHSBPIZNUXPLA

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.252
Position:
46870761
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
15.694
Reference Allele:
C
-log10(P):
-126.135
MAF:
0.209
Beta (Num):
0.267
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.015
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid amide/endocannabinoid metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid alpha-oxidation/sphingolipid metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects FAAH activity; reduced function increases oleoyl ethanolamide, while 2-hydroxypalmitate, from an independent pathway, remains unaffected.3[1], 1[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype is associated. Reduced FAAH activity, due to a missense variant, increases levels of its substrate oleoyl ethanolamide relative to 2-hydroxypalmitate.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data