oleoyl ethanolamide to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Structure of oleoyl ethanolamide
Metabolite Accession: GCST90200299
Name: oleoyl ethanolamide
Hmdb Id: HMDB0002088
Super Pathway: NA
Sub Pathway: NA
Inchikey: BOWVQLFMWHZBEF

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs174536

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.139
Position:
61551927
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
9.118
Reference Allele:
A
-log10(P):
-44.020
MAF:
0.342
Beta (Num):
0.026
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.113
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

N-acylethanolamine biosynthesis4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Omega-6 fatty acid biosynthesis7[1], 8[2]

Ratio Explanation:

The ratio reflects FADS desaturase activity; lower FADS function decreases docosapentaenoate (denominator) and may increase oleoyl ethanolamide precursors (numerator), elevating the ratio.9[1], 1[2], 10[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter polyunsaturated fatty acid metabolism, influencing the risk for disorders of lipoprotein metabolism, cholelithiasis, and type 2 diabetes, which are strongly associated with lipid profiles and inflammation.9[1], 3[2], 11[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data