oleoyl ethanolamide to dihomo-linolenate (20:3n3 or n6)

Numerator Metabolite

Structure of oleoyl ethanolamide
Metabolite Accession: GCST90200299
Name: oleoyl ethanolamide
Hmdb Id: HMDB0002088
Super Pathway: NA
Sub Pathway: NA
Inchikey: BOWVQLFMWHZBEF

Denominator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.279
Position:
46870761
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
18.330
Reference Allele:
C
-log10(P):
-171.138
MAF:
0.209
Beta (Num):
0.267
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.012
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Endocannabinoid-like lipid synthesis, N-acylethanolamine metabolism.8[1], 9[2], 10[3]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid (PUFA) biosynthesis (omega-6).11[1], 12[2], 13[3], 14[4]

Ratio Explanation:

The ratio reflects FAAH-mediated degradation of oleoyl ethanolamide and FADS1-controlled conversion of dihomo-linolenate, linking endocannabinoid signaling to PUFA metabolism.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter polyunsaturated fatty acid profiles, affecting the balance of pro- and anti-inflammatory lipid mediators.15[1], 16[2] This dysregulation likely underlies the associated inflammatory skin conditions and observed changes in blood lipids and cell counts.17[3], 18[4], 19[5], 20[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data