oleoyl ethanolamide to palmitoleoylcarnitine (c16:1)*

Numerator Metabolite

Structure of oleoyl ethanolamide
Metabolite Accession: GCST90200299
Name: oleoyl ethanolamide
Hmdb Id: HMDB0002088
Super Pathway: NA
Sub Pathway: NA
Inchikey: BOWVQLFMWHZBEF

Denominator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.279
Position:
46870761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
16.445
Reference Allele:
C
-log10(P):
-138.256
MAF:
0.209
Beta (Num):
0.267
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.013
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Endocannabinoid signaling, Fatty acid metabolism3[1], 4[2], 6[3], 7[4]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, Carnitine shuttle8[1], 9[2]

Ratio Explanation:

The ratio reflects the rate of oleoyl ethanolamide degradation by FAAH relative to the transport of fatty acids for beta-oxidation, indicating a balance between signaling and energy metabolism.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

A variant in FAAH altering its function could disrupt the degradation of oleoyl ethanolamide, potentially impacting signaling pathways related to energy balance and behavior; however, no direct phenotype link is established here.5[1], 2[2]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data