oleoyl ethanolamide to 3-hydroxyoleoylcarnitine

Numerator Metabolite

Metabolite Accession: GCST90200299

Name: oleoyl ethanolamide

Hmdb Id: HMDB0002088

Super Pathway: NA

Sub Pathway: NA

Inchikey: BOWVQLFMWHZBEF

Denominator Metabolite

Metabolite Accession: GCST90200158

Name: 3-hydroxyoleoylcarnitine

Hmdb Id: HMDB0240761

Super Pathway: NA

Sub Pathway: NA

Inchikey: YBCVTTMMURGSEY

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:

Beta (Ratio):

0.332

Position:

46870761

SE (Ratio):

0.020

Effect Allele:

Z-score (Ratio):

16.700

Reference Allele:

-log10(P):

-142.484

MAF:

0.209

Beta (Num):

0.267

Novel Locus:

SE (Num):

0.018

Beta (Den):

-0.065

SE (Den):

0.019

No CNV overlap

rQTL cluster:

164

Reaction Distance:

Closest Genes:

FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Endocannabinoid signaling, Fatty acid metabolism.5^[1], 9^[2], 10^[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.11^[1]

Ratio Explanation:

This ratio reflects FAAH activity; reduced FAAH function from a missense variant would increase oleoyl ethanolamide, thus elevating the ratio against 3-hydroxyoleoylcarnitine levels.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data