oleoyl ethanolamide to stearate (18:0)

Numerator Metabolite

Structure of oleoyl ethanolamide
Metabolite Accession: GCST90200299
Name: oleoyl ethanolamide
Hmdb Id: HMDB0002088
Super Pathway: NA
Sub Pathway: NA
Inchikey: BOWVQLFMWHZBEF

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.298
Position:
46870761
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
20.523
Reference Allele:
C
-log10(P):
-213.837
MAF:
0.209
Beta (Num):
0.267
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.032
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.169
Position:
102075479
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-10.821
Reference Allele:
G
-log10(P):
-61.159
MAF:
0.176
Beta (Num):
-0.072
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.097
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

N-acylethanolamine biosynthesis9[1], 10[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis11[1], 12[2]

Ratio Explanation:

The ratio of oleoyl ethanolamide to stearate may reflect the balance between fatty acid synthesis/desaturation (SCD) and fatty acid amide degradation (FAAH).

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced FAAH activity increases oleoylethanolamide, which has shown atheroprotective effects; however, lower FAAH activity is also linked to an increased risk of myocardial infarction and atherosclerosis, suggesting a complex relationship.13[1], 14[2], 15[3], 16[4]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data