oleoyl ethanolamide to palmitate (16:0)

Numerator Metabolite

Structure of oleoyl ethanolamide
Metabolite Accession: GCST90200299
Name: oleoyl ethanolamide
Hmdb Id: HMDB0002088
Super Pathway: NA
Sub Pathway: NA
Inchikey: BOWVQLFMWHZBEF

Denominator Metabolite

Structure of palmitate (16:0)
Metabolite Accession: GCST90200397
Name: palmitate (16:0)
Hmdb Id: HMDB0000220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IPCSVZSSVZVIGE

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.288
Position:
46870761
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
20.259
Reference Allele:
C
-log10(P):
-208.458
MAF:
0.209
Beta (Num):
0.267
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.022
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
3.0
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.118
Position:
102075479
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-7.752
Reference Allele:
G
-log10(P):
-32.333
MAF:
0.176
Beta (Num):
-0.072
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.046
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
3.0
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid amide metabolism, endocannabinoid signaling.8[1], 9[2], 10[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, ceramide synthesis, beta-oxidation.11[1], 12[2], 13[3]

Ratio Explanation:

The ratio reflects the degradation of oleoyl ethanolamide by FAAH relative to the availability of palmitate, a foundational saturated fatty acid.5[1], 12[2], 6[3], 10[4]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Impaired FAAH function may increase oleoyl ethanolamide levels, altering lipid signaling.14[1], 15[2], 16[3] This disruption in fatty acid homeostasis is a plausible contributor to the associated phenotypes of dyslipidemia and coronary atherosclerosis.14[4], 17[5], 18[6], 19[7], 20[8], 21[9]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data