oleoyl ethanolamide to pentadecanoate (15:0)

Numerator Metabolite

Structure of oleoyl ethanolamide
Metabolite Accession: GCST90200299
Name: oleoyl ethanolamide
Hmdb Id: HMDB0002088
Super Pathway: NA
Sub Pathway: NA
Inchikey: BOWVQLFMWHZBEF

Denominator Metabolite

Structure of pentadecanoate (15:0)
Metabolite Accession: GCST90200457
Name: pentadecanoate (15:0)
Hmdb Id: HMDB0000826
Super Pathway: NA
Sub Pathway: NA
Inchikey: WQEPLUUGTLDZJY

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.273
Position:
46870761
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
16.612
Reference Allele:
C
-log10(P):
-141.012
MAF:
0.209
Beta (Num):
0.267
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.007
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Endocannabinoid metabolism, Fatty acid amide degradation.6[1], 10[2], 11[3], 12[4], 13[5], 14[6]

Denominator Metabolite Explanation:

Fatty acid metabolism, beta-oxidation.15[1], 16[2], 17[3], 18[4], 19[5]

Ratio Explanation:

An increased ratio of oleoyl ethanolamide to pentadecanoate could indicate reduced FAAH enzyme activity, leading to higher levels of the numerator.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype data was provided, so a direct link between the gene, ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data