oleoyl ethanolamide to margarate (17:0)

Numerator Metabolite

Structure of oleoyl ethanolamide
Metabolite Accession: GCST90200299
Name: oleoyl ethanolamide
Hmdb Id: HMDB0002088
Super Pathway: NA
Sub Pathway: NA
Inchikey: BOWVQLFMWHZBEF

Denominator Metabolite

Structure of margarate (17:0)
Metabolite Accession: GCST90200459
Name: margarate (17:0)
Hmdb Id: HMDB0002259
Super Pathway: NA
Sub Pathway: NA
Inchikey: KEMQGTRYUADPNZ

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.285
Position:
46870761
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
18.839
Reference Allele:
C
-log10(P):
-180.620
MAF:
0.209
Beta (Num):
0.267
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.019
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.148
Position:
102075479
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-9.106
Reference Allele:
G
-log10(P):
-43.909
MAF:
0.176
Beta (Num):
-0.072
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.076
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid amide metabolism.3[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism (exogenous).6[1], 7[2]

Ratio Explanation:

A higher ratio indicates decreased FAAH activity, leading to the accumulation of oleoyl ethanolamide relative to margarate, an unrelated dietary fatty acid.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FAAH function increases levels of substrates like oleoyl ethanolamide, which may influence cardiovascular health through PPAR-alpha signaling and inflammatory pathways, potentially increasing the risk for atherosclerosis and myocardial infarction.8[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data