alpha-tocopherol to 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*

Numerator Metabolite

Structure of alpha-tocopherol
Metabolite Accession: GCST90200302
Name: alpha-tocopherol
Hmdb Id: HMDB0001893
Super Pathway: NA
Sub Pathway: NA
Inchikey: GVJHHUAWPYXKBD

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*
Metabolite Accession: GCST90200060
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*
Hmdb Id: HMDB0011211
Super Pathway: NA
Sub Pathway: NA
Inchikey: QLEHHUPUHJPURI

Associated Genomic Regions

Region: rs964184

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.234
Position:
116648917
SE (Ratio):
0.030
Effect Allele:
G
Z-score (Ratio):
7.740
Reference Allele:
C
-log10(P):
-32.243
MAF:
0.131
Beta (Num):
0.117
Novel Locus:
Yes ✔️
SE (Num):
0.023
Beta (Den):
-0.117
SE (Den):
0.023
No CNV overlap
rQTL cluster:
248
Reaction Distance:
NA
Closest Genes:
ZNF259 BUD13 APOA5 APOA4 APOC3

LLM Analysis

Numerator Metabolite Explanation:

Vitamin E metabolism, lipoprotein transport.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Plasmalogen synthesis, ether phospholipid metabolism.9[1], 10[2], 11[3]

Ratio Explanation:

This ratio reflects the balance of the antioxidant alpha-tocopherol to a specific plasmalogen within circulating lipoproteins, a composition heavily influenced by apolipoprotein genetics.12[1], 13[2], 14[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in the APOA1/C3/A4/A5 cluster, particularly APOA5, alter triglyceride and lipoprotein metabolism, which is reflected in the metabolite ratio.1[1], 15[2], 16[3], 17[4] This genetically-driven dyslipidemia is a primary cause for the associated phenotypes of hypercholesterolemia, atherosclerosis, and myocardial infarction.18[5], 19[6], 20[7], 21[8]

Phenotype Driver:

Gene-centric:APOA5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data