2-aminobutyrate to hexanoylglutamine

Numerator Metabolite

Structure of 2-aminobutyrate
Metabolite Accession: GCST90200305
Name: 2-aminobutyrate
Hmdb Id: HMDB0000452
Super Pathway: NA
Sub Pathway: NA
Inchikey: QWCKQJZIFLGMSD

Denominator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Associated Genomic Regions

Region: rs7302925

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
12
Beta (Ratio):
0.182
Position:
56861458
SE (Ratio):
0.024
Effect Allele:
A
Z-score (Ratio):
7.744
Reference Allele:
G
-log10(P):
-32.274
MAF:
0.212
Beta (Num):
0.095
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
-0.087
SE (Den):
0.019
No CNV overlap
rQTL cluster:
51
Reaction Distance:
NA
Closest Genes:
MIP SPRYD4 GLS2 TIMELESS RBMS2

LLM Analysis

Numerator Metabolite Explanation:

Amino acid metabolism (methionine, threonine).3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid detoxification, glutamine conjugation.5[1]

Ratio Explanation:

Altered GLS2 activity may modulate glutamine availability for hexanoylglutamine synthesis, while influencing pathways producing 2-aminobutyrate, thus impacting the ratio.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered GLS2-mediated glutaminolysis in the liver and kidney likely impacts nitrogen balance (BUN, Uric Acid), inflammation (CRP), and related liver function markers (Albumin, Bilirubin) and red blood cell homeostasis.2[1], 6[2], 7[3]

Phenotype Driver:

Gene-centric:GLS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data