vanillylmandelate (vma) to cortolone glucuronide (1)

Numerator Metabolite

Structure of vanillylmandelate (vma)
Metabolite Accession: GCST90200309
Name: vanillylmandelate (vma)
Hmdb Id: HMDB0000291
Super Pathway: NA
Sub Pathway: NA
Inchikey: CGQCWMIAEPEHNQ

Denominator Metabolite

Structure of cortolone glucuronide (1)
Metabolite Accession: GCST90200156
Name: cortolone glucuronide (1)
Hmdb Id: HMDB0010320
Super Pathway: NA
Sub Pathway: NA
Inchikey: OKNSFVSKHQJVRN

Associated Genomic Regions

Region: rs13112099

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
-0.294
Position:
69537733
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
-15.719
Reference Allele:
T
-log10(P):
-126.536
MAF:
0.470
Beta (Num):
-0.188
Novel Locus:
No
SE (Num):
0.013
Beta (Den):
0.106
SE (Den):
0.015
No CNV overlap
rQTL cluster:
123
Reaction Distance:
NA
Closest Genes:
UGT2B15 UGT2B17 UGT2B10 TMPRSS11E UGT2A3

LLM Analysis

Numerator Metabolite Explanation:

Catecholamine metabolism7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Steroid biosynthesis and metabolism10[1], 11[2], 12[3]

Ratio Explanation:

This ratio may reflect UGT2B15's efficiency in steroid glucuronidation (denominator) relative to catecholamine breakdown (numerator), as UGT2B15 activity influences cortolone glucuronide formation.13[1], 10[2], 6[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

UGT2B15's primary role in drug and steroid metabolism likely drives the associated phenotypes (GGT, ALP, cholesterol, MCH, MCV). Altered steroid clearance by UGT2B15 can systemically affect liver function, lipid profiles, and hematological parameters, explaining the link to the observed biomarkers.14[1], 15[2], 16[3], 17[4]

Phenotype Driver:

Gene-centric:UGT2B15

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data