dihomo-linoleate (20:2n6) to adrenate (22:4n6)

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Associated Genomic Regions

Region: rs174567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.202
Position:
61593005
SE (Ratio):
0.009
Effect Allele:
G
Z-score (Ratio):
23.421
Reference Allele:
A
-log10(P):
-277.656
MAF:
0.346
Beta (Num):
0.023
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.179
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio of dihomo-linoleate (an early precursor) to adrenate (a downstream product) reflects the efficiency of the FADS-mediated polyunsaturated fatty acid synthesis pathway.1[1], 4[2], 6[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity dysregulates polyunsaturated fatty acid metabolism, impacting the balance of inflammatory mediators.9[1], 10[2] This is linked to phenotypes like cholelithiasis, dermatitis, and metabolic syndromes by affecting inflammation and lipid homeostasis.11[3], 12[4], 13[5], 14[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data