dihomo-linoleate (20:2n6) to docosatrienoate (22:3n3)

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs968567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.284
Position:
61595564
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-17.798
Reference Allele:
C
-log10(P):
-161.497
MAF:
0.179
Beta (Num):
-0.005
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.278
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Alpha-linolenic and linoleic acid metabolism.5[1]

Denominator Metabolite Explanation:

Long-chain polyunsaturated fatty acid (n-3 and n-6) pathway.6[1]

Ratio Explanation:

This ratio reflects the relative activity of fatty acid desaturase enzymes, where higher values may indicate increased conversion of precursors into these longer-chain fatty acids.7[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in FADS1/FADS2 alter enzyme activity, impacting the balance of omega-6 and omega-3 fatty acids.7[1], 9[2] This altered ratio is associated with inflammatory conditions like asthma and dermatitis and affects lipid profiles (HDL, LDL, triglycerides), potentially explaining the link to these phenotypes.1[3], 7[4], 10[5], 11[6], 12[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data