dihomo-linoleate (20:2n6) to stearidonate (18:4n3)

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.142
Position:
61592362
SE (Ratio):
0.011
Effect Allele:
G
Z-score (Ratio):
12.584
Reference Allele:
A
-log10(P):
-81.940
MAF:
0.345
Beta (Num):
0.024
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.118
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

omega-6 fatty acid biosynthesis

Denominator Metabolite Explanation:

omega-3 fatty acid biosynthesis

Ratio Explanation:

This ratio reflects the relative activity of parallel omega-6 and omega-3 fatty acid synthesis pathways, influenced by FADS enzyme efficiency.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter enzyme activity, impacting the balance of omega-6 and omega-3 fatty acids.6[1], 7[2], 8[3], 9[4] This imbalance is associated with altered lipid profiles and an increased risk for cholesterol-related phenotypes like cholelithiasis and pure hypercholesterolaemia, as well as type 2 diabetes.10[5], 11[6], 12[7], 13[8], 14[9]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data