dihomo-linoleate (20:2n6) to 5-dodecenoate (12:1n7)

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs2130525

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.082
Position:
151902101
SE (Ratio):
0.011
Effect Allele:
T
Z-score (Ratio):
7.705
Reference Allele:
C
-log10(P):
-31.964
MAF:
0.392
Beta (Num):
0.013
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.069
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.128
Position:
102075479
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
9.361
Reference Allele:
G
-log10(P):
-46.292
MAF:
0.176
Beta (Num):
0.016
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
-0.112
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Omega-6 fatty acid biosynthesis.3[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.4[1], 5[2]

Ratio Explanation:

The ratio may reflect the activity of desaturase and elongase enzymes involved in fatty acid metabolism, influenced by the SCD gene.1[1], 3[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

SCD-1 deficiency is linked to reduced adiposity and increased insulin sensitivity but can also promote atherosclerosis under hyperlipidemic conditions.6[1], 7[2] Altered SCD activity impacts fatty acid composition, contributing to cardiovascular disease phenotypes like hypercholesterolemia and myocardial infarction.7[3], 8[4]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data