dihomo-linoleate (20:2n6) to 10-heptadecenoate (17:1n7)

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of 10-heptadecenoate (17:1n7)
Metabolite Accession: GCST90199731
Name: 10-heptadecenoate (17:1n7)
Hmdb Id: HMDB0060038
Super Pathway: NA
Sub Pathway: NA
Inchikey: GDTXICBNEOEPAZ

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.072
Position:
102075479
SE (Ratio):
0.009
Effect Allele:
A
Z-score (Ratio):
7.905
Reference Allele:
G
-log10(P):
-33.551
MAF:
0.176
Beta (Num):
0.016
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
-0.056
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects Stearoyl-CoA Desaturase (SCD) activity, which influences the balance between different fatty acid species.10[1], 11[2], 12[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered SCD gene function likely modifies the fatty acid profile, increasing the dihomo-linoleate to 10-heptadecenoate ratio. This imbalance is associated with an increased risk for cardiovascular diseases like myocardial infarction and hypertension, potentially through effects on lipid metabolism and inflammation.13[1], 14[2]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data