dihomo-linoleate (20:2n6) to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs174570

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.196
Position:
61597212
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
12.469
Reference Allele:
C
-log10(P):
-80.495
MAF:
0.131
Beta (Num):
0.034
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
-0.162
SE (Den):
0.023
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-6 fatty acid biosynthesis

Denominator Metabolite Explanation:

Omega-6 fatty acid biosynthesis

Ratio Explanation:

This ratio reflects the efficiency of the polyunsaturated fatty acid (PUFA) synthesis cascade, where lower FADS1/FADS2 activity can increase substrate-to-product ratios.3[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS gene cluster alter desaturase enzyme activity, modifying the balance of omega-6 fatty acids.4[1] This dysregulation of PUFA metabolism contributes to phenotypes like hypercholesterolemia, other lipoprotein disorders, and Type 2 diabetes.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data