dihomo-linoleate (20:2n6) to dihomo-linolenate (20:3n3 or n6)

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Associated Genomic Regions

Region: rs968567

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.150
Position:
61595564
SE (Ratio):
0.010
Effect Allele:
T
Z-score (Ratio):
-15.477
Reference Allele:
C
-log10(P):
-122.740
MAF:
0.179
Beta (Num):
-0.005
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.145
SE (Den):
0.020
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs12928099

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.096
Position:
15150505
SE (Ratio):
0.008
Effect Allele:
A
Z-score (Ratio):
-11.690
Reference Allele:
C
-log10(P):
-71.025
MAF:
0.291
Beta (Num):
0.005
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.100
SE (Den):
0.016
No CNV overlap
rQTL cluster:
34
Reaction Distance:
NA
Closest Genes:
PDXDC1 NTAN1 RRN3 NPIPA1 NOMO1

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid and alpha-linolenic acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Linoleic acid and alpha-linolenic acid metabolism.4[1], 5[2]

Ratio Explanation:

The ratio reflects the efficiency of FADS1/FADS2 desaturase activity, where a lower ratio suggests reduced conversion of dihomo-linoleate to downstream pro-inflammatory lipids.1[1], 2[2], 3[3]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

FADS1/FADS2 variants influence the balance of fatty acids.1[1], 6[2], 7[3] Altered fatty acid levels, including those linked to inflammation, are associated with seborrhoeic dermatitis.8[4], 9[5], 10[6] This suggests a genetic predisposition to inflammatory skin conditions through altered lipid metabolism.11[7], 12[8], 13[9]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data