dihomo-linoleate (20:2n6) to hexanoylglutamine

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Associated Genomic Regions

Region: rs1177442

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
0.327
Position:
25809069
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
22.621
Reference Allele:
G
-log10(P):
-259.194
MAF:
0.444
Beta (Num):
0.010
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.318
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism, Biosynthesis of unsaturated fatty acids4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism6[1]

Ratio Explanation:

A higher ratio may indicate altered fatty acid metabolism, potentially influenced by SLC17A4's role as a transporter of various organic anions, including urate.

Ratio Evidence:

metabolites unrelated

Gene Ratio Phenotype Relationship:

The SLC17A4 gene, a known urate and thyroid hormone transporter, is linked to phenotypes related to erythrocyte indices (hemoglobin, hematocrit), and serum urate.7[1], 1[2], 8[3], 9[4], 10[5], 11[6] Alterations in SLC17A4 function likely impact these phenotypes directly, with the metabolite ratio being a secondary consequence.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data