dihomo-linoleate (20:2n6) to cis-4-decenoate (10:1n6)*

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of cis-4-decenoate (10:1n6)*
Metabolite Accession: GCST90199893
Name: cis-4-decenoate (10:1n6)*
Hmdb Id: HMDB0004980
Super Pathway: NA
Sub Pathway: NA
Inchikey: XKZKQTCECFWKBN

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.431
Position:
151879761
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
29.903
Reference Allele:
G
-log10(P):
-450.727
MAF:
0.318
Beta (Num):
0.022
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.409
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism, Polyunsaturated Fatty Acid (n3 and n6) pathway.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Fatty Acid Metabolism (Beta-Oxidation).1[1], 9[2]

Ratio Explanation:

An elevated ratio of dihomo-linoleate to cis-4-decenoate may indicate reduced ACADM activity, as cis-4-decenoate accumulates in MCAD deficiency.10[1], 11[2], 12[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data