dihomo-linoleate (20:2n6) to linoleoyl ethanolamide

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of linoleoyl ethanolamide
Metabolite Accession: GCST90200029
Name: linoleoyl ethanolamide
Hmdb Id: HMDB0012252
Super Pathway: NA
Sub Pathway: NA
Inchikey: KQXDGUVSAAQARU

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.253
Position:
46870761
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-14.414
Reference Allele:
C
-log10(P):
-106.779
MAF:
0.208
Beta (Num):
-0.030
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.224
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism.8[1]

Denominator Metabolite Explanation:

Endocannabinoid signaling pathway.9[1], 10[2]

Ratio Explanation:

The ratio reflects FAAH activity; a higher ratio suggests reduced FAAH function, leading to the accumulation of linoleoyl ethanolamide, a FAAH substrate.5[1], 10[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

A missense variant in FAAH decreases its enzymatic activity, leading to an accumulation of its substrate, linoleoyl ethanolamide, and a subsequent increase in the dihomo-linoleate to linoleoyl ethanolamide ratio; however, no associated phenotype is provided.1[1], 2[2], 10[3]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data