dihomo-linoleate (20:2n6) to docosatrienoate (22:3n6)*

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of docosatrienoate (22:3n6)*
Metabolite Accession: GCST90200138
Name: docosatrienoate (22:3n6)*
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs174533

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.213
Position:
61549025
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
11.604
Reference Allele:
G
-log10(P):
-70.009
MAF:
0.339
Beta (Num):
0.019
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.194
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism

Denominator Metabolite Explanation:

Linoleic acid metabolism

Ratio Explanation:

The ratio reflects the activity of FADS-mediated desaturation in the omega-6 fatty acid pathway, where dihomo-linoleate is an upstream precursor to docosatrienoate.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter desaturase efficiency, impacting the dihomo-linoleate to docosatrienoate ratio.3[1], 4[2] This dysregulation of PUFA metabolism is associated with altered plasma lipid profiles and inflammatory responses, plausibly contributing to phenotypes like pure hypercholesterolaemia and cholelithiasis.5[3], 6[4], 7[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data