dihomo-linoleate (20:2n6) to tetradecadienoate (14:2)*

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.146
Position:
151879761
SE (Ratio):
0.010
Effect Allele:
A
Z-score (Ratio):
14.075
Reference Allele:
G
-log10(P):
-101.934
MAF:
0.318
Beta (Num):
0.022
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.123
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs11626972

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.083
Position:
74033594
SE (Ratio):
0.010
Effect Allele:
G
Z-score (Ratio):
8.415
Reference Allele:
A
-log10(P):
-37.773
MAF:
0.423
Beta (Num):
-0.002
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.085
SE (Den):
0.015
No CNV overlap
rQTL cluster:
43
Reaction Distance:
NA
Closest Genes:
ACOT2 HEATR4 ACOT1 ACOT4 ACOT6

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism, fatty acid elongation.4[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.

Ratio Explanation:

The ratio reflects the balance between long-chain (dihomo-linoleate) and medium-chain (tetradecadienoate) fatty acid metabolism, potentially modulated by ACOT2/THEM4 activity.1[1], 5[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data