dihomo-linoleate (20:2n6) to eicosapentaenoate (epa; 20:5n3)

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of eicosapentaenoate (epa; 20:5n3)
Metabolite Accession: GCST90200349
Name: eicosapentaenoate (epa; 20:5n3)
Hmdb Id: HMDB0001999
Super Pathway: NA
Sub Pathway: NA
Inchikey: JAZBEHYOTPTENJ

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.225
Position:
61592362
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
16.149
Reference Allele:
A
-log10(P):
-133.400
MAF:
0.345
Beta (Num):
0.024
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.201
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

n-6 polyunsaturated fatty acid biosynthesis

Denominator Metabolite Explanation:

n-3 polyunsaturated fatty acid biosynthesis4[1]

Ratio Explanation:

This ratio reflects the balance between omega-6 and omega-3 fatty acid metabolism.5[1] It is influenced by FADS1/FADS2 enzyme activity which is essential for both pathways.1[2], 2[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in FADS1/FADS2 alter enzyme activity, thereby changing the balance of n-6/n-3 fatty acids.3[1], 5[2] This dysregulation can impact inflammatory and lipid pathways, contributing to phenotypes like cholelithiasis, type 2 diabetes, and hypercholesterolemia.6[3], 2[4], 7[5], 8[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data