dihomo-linoleate (20:2n6) to arachidonate (20:4n6)

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.336
Position:
61588305
SE (Ratio):
0.010
Effect Allele:
G
Z-score (Ratio):
33.000
Reference Allele:
A
-log10(P):
-548.209
MAF:
0.344
Beta (Num):
0.021
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.314
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism

Denominator Metabolite Explanation:

Arachidonic acid metabolism

Ratio Explanation:

The ratio of dihomo-linoleate to arachidonate reflects the enzymatic efficiency of FADS1, which converts the numerator to the denominator.5[1] A lower ratio indicates higher FADS1 activity.5[2]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 and FADS2 are associated with altered levels of polyunsaturated fatty acids.6[1], 7[2], 8[3] An increased arachidonic acid to linoleic acid ratio, indicative of higher FADS activity, is associated with aortic valve calcification and stenosis.9[4], 10[5] The FADS locus is also linked to cholesterol levels and inflammatory conditions.6[6], 11[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data