dihomo-linoleate (20:2n6) to palmitoleate (16:1n7)

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.144
Position:
102075479
SE (Ratio):
0.010
Effect Allele:
A
Z-score (Ratio):
14.586
Reference Allele:
G
-log10(P):
-109.291
MAF:
0.176
Beta (Num):
0.016
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.128
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism

Denominator Metabolite Explanation:

De novo lipogenesis

Ratio Explanation:

The ratio reflects Stearoyl-CoA Desaturase (SCD) activity, where higher values suggest reduced SCD-mediated synthesis of palmitoleate relative to dihomo-linoleate.1[1], 3[2], 5[3], 6[4]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in SCD alters its desaturase activity, modifying the dihomo-linoleate to palmitoleate ratio.1[1], 3[2] This imbalance in fatty acids is linked to dyslipidemia and contributes to increased risk for coronary atherosclerosis, myocardial infarction, and hypertension, as seen in the FinnGen traits.3[3], 5[4], 7[5]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data