beta-hydroxyisovalerate to glycine conjugate of c10h14o2 (1)*

Numerator Metabolite

Metabolite Accession: GCST90200322
Name: beta-hydroxyisovalerate
Hmdb Id: HMDB0000754
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200175
Name: glycine conjugate of c10h14o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs11204915

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.224
Position:
151882826
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
-11.001
Reference Allele:
T
-log10(P):
-63.144
MAF:
0.398
Beta (Num):
-0.107
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.117
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D S100A10 RORC

LLM Analysis

Numerator Metabolite Explanation:

Leucine catabolism.2[1], 3[2]

Denominator Metabolite Explanation:

Xenobiotic metabolism, glycine conjugation.4[1], 5[2]

Ratio Explanation:

This ratio compares leucine breakdown to xenobiotic detoxification. THEM4's broad thioesterase activity could modulate both pathways by acting on their respective acyl-CoA intermediates.6[1], 7[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No associated phenotype was provided, thus a causal link between genetic modulation of THEM4, the resulting metabolite ratio, and a clinical outcome cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data