beta-hydroxyisovalerate to n-acetylvaline

Numerator Metabolite

Metabolite Accession: GCST90200322
Name: beta-hydroxyisovalerate
Hmdb Id: HMDB0000754
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of n-acetylvaline
Metabolite Accession: GCST90200287
Name: n-acetylvaline
Hmdb Id: HMDB0011757
Super Pathway: NA
Sub Pathway: NA
Inchikey: IHYJTAOFMMMOPX

Associated Genomic Regions

Region: rs2338201

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.167
Position:
151845650
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
-9.820
Reference Allele:
C
-log10(P):
-50.732
MAF:
0.394
Beta (Num):
-0.109
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.059
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC LINGO4

LLM Analysis

Numerator Metabolite Explanation:

Leucine degradation, Biotin metabolism.5[1], 6[2], 7[3], 8[4]

Denominator Metabolite Explanation:

Valine metabolism, protein acetylation.9[1], 10[2]

Ratio Explanation:

The ratio may reflect altered branched-chain amino acid metabolism, but a direct link between beta-hydroxyisovalerate and n-acetylvaline through THEM4 is not established.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data