glycerol to adrenate (22:4n6)

Numerator Metabolite

Structure of glycerol
Metabolite Accession: GCST90200325
Name: glycerol
Hmdb Id: HMDB0000131
Super Pathway: NA
Sub Pathway: NA
Inchikey: PEDCQBHIVMGVHV

Denominator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.172
Position:
61557803
SE (Ratio):
0.013
Effect Allele:
C
Z-score (Ratio):
12.787
Reference Allele:
T
-log10(P):
-84.531
MAF:
0.346
Beta (Num):
-0.010
Novel Locus:
No
SE (Num):
0.014
Beta (Den):
-0.182
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerol Kinase/Dehydrogenase pathways5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis/desaturation1[1], 7[2], 8[3], 9[4]

Ratio Explanation:

The ratio reflects fatty acid desaturation efficiency, where FADS1 activity influences the balance between glycerol, a triglyceride backbone, and adrenate, a long-chain polyunsaturated fatty acid.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity, indicated by the glycerol to adrenate ratio, alters lipid profiles, contributing to dyslipidemia and increasing the risk for cardiovascular diseases, type 2 diabetes, and inflammatory conditions like IBD, as supported by associations with various cardiometabolic traits.10[1], 11[2], 12[3], 13[4], 14[5], 15[6], 16[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data