glycerol to myristoleate (14:1n5)

Numerator Metabolite

Structure of glycerol
Metabolite Accession: GCST90200325
Name: glycerol
Hmdb Id: HMDB0000131
Super Pathway: NA
Sub Pathway: NA
Inchikey: PEDCQBHIVMGVHV

Denominator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.112
Position:
102075479
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
7.926
Reference Allele:
G
-log10(P):
-33.719
MAF:
0.176
Beta (Num):
0.015
Novel Locus:
Yes ✔️
SE (Num):
0.018
Beta (Den):
-0.097
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Triglyceride synthesis3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis5[1], 6[2]

Ratio Explanation:

The ratio of glycerol to myristoleate may reflect the balance between triglyceride synthesis and fatty acid desaturation, influenced by SCD activity.3[1], 1[2], 2[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SCD activity can decrease myristoleate synthesis, potentially altering membrane fluidity and signaling, which may contribute to cardiovascular phenotypes like myocardial infarction and hypertension.1[1], 7[2], 8[3]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data