glycerol to 5-dodecenoate (12:1n7)

Numerator Metabolite

Structure of glycerol
Metabolite Accession: GCST90200325
Name: glycerol
Hmdb Id: HMDB0000131
Super Pathway: NA
Sub Pathway: NA
Inchikey: PEDCQBHIVMGVHV

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.127
Position:
102075479
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
8.473
Reference Allele:
G
-log10(P):
-38.268
MAF:
0.176
Beta (Num):
0.015
Novel Locus:
Yes ✔️
SE (Num):
0.018
Beta (Den):
-0.112
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Glycerolipid metabolism, gluconeogenesis, glycolysis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, beta-oxidation.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio of glycerol to 5-dodecenoate may reflect the balance between triglyceride breakdown (releasing glycerol) and monounsaturated fatty acid synthesis, influenced by SCD activity.1[1], 5[2], 3[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

SCD is the rate-limiting enzyme in monounsaturated fatty acid synthesis, and its activity is linked to hypertriglyceridemia and atherosclerosis.1[1], 10[2] Altered SCD function likely affects the balance of lipid species, contributing to the observed cardiovascular and metabolic phenotypes.11[3], 12[4]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data