glycerol to palmitoleate (16:1n7)

Numerator Metabolite

Structure of glycerol
Metabolite Accession: GCST90200325
Name: glycerol
Hmdb Id: HMDB0000131
Super Pathway: NA
Sub Pathway: NA
Inchikey: PEDCQBHIVMGVHV

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
10
Beta (Ratio):
0.143
Position:
102075479
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
10.340
Reference Allele:
G
-log10(P):
-56.034
MAF:
0.176
Beta (Num):
0.015
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.128
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Glycerolipid metabolism, glycolysis, gluconeogenesis3[1], 4[2]

Denominator Metabolite Explanation:

Monounsaturated fatty acid biosynthesis5[1], 6[2]

Ratio Explanation:

This ratio may reflect the balance between triglyceride breakdown (releasing glycerol) and fatty acid desaturation (forming palmitoleate), which is catalyzed by SCD.2[1], 4[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SCD activity, reflected by the glycerol to palmitoleate ratio, impacts lipid profiles and is associated with dyslipidemia and cardiovascular diseases like myocardial infarction.7[1], 1[2], 8[3] Variation in SCD can affect cardiovascular risk by modulating lipid metabolism.

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data