gamma-glutamylleucine to propionylcarnitine (c3)

Numerator Metabolite

Structure of gamma-glutamylleucine
Metabolite Accession: GCST90200326
Name: gamma-glutamylleucine
Hmdb Id: HMDB0011171
Super Pathway: NA
Sub Pathway: NA
Inchikey: MYFMARDICOWMQP

Denominator Metabolite

Structure of propionylcarnitine (c3)
Metabolite Accession: GCST90199708
Name: propionylcarnitine (c3)
Hmdb Id: HMDB0000824
Super Pathway: NA
Sub Pathway: NA
Inchikey: UFAHZIUFPNSHSL

Associated Genomic Regions

Region: rs12356193

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.258
Position:
61413353
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
12.874
Reference Allele:
A
-log10(P):
-85.650
MAF:
0.166
Beta (Num):
0.039
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-0.219
SE (Den):
0.020
No CNV overlap
rQTL cluster:
74
Reaction Distance:
NA
Closest Genes:
SLC16A9 CCDC6 FAM13C C10orf40 ANK3

LLM Analysis

Numerator Metabolite Explanation:

Glutathione metabolism, Protein catabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, Amino acid catabolism.6[1], 7[2]

Ratio Explanation:

The ratio may reflect altered mitochondrial function and oxidative stress, where SLC16A9 dysfunction impacts both carnitine-dependent metabolism and processes influencing gamma-glutamylleucine levels.1[1], 5[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC16A9 function likely impacts carnitine transport (affecting propionylcarnitine) and urate excretion, leading to hyperuricemia and gout.1[1], 2[2], 8[3], 3[4] The ratio change reflects the underlying metabolic disruption, including oxidative stress, associated with this process.5[5]

Phenotype Driver:

Gene-centric:SLC16A9

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data