3-methoxytyrosine to carnitine C18:2

Numerator Metabolite

Structure of 3-methoxytyrosine
Metabolite Accession: GCST90200328
Name: 3-methoxytyrosine
Hmdb Id: HMDB0001434
Super Pathway: NA
Sub Pathway: NA
Inchikey: PFDUUKDQEHURQC

Denominator Metabolite

Structure of linoleoylcarnitine (c18:2)*
Metabolite Accession: GCST90199916
Name: linoleoylcarnitine (c18:2)*
Hmdb Id: HMDB0006469
Super Pathway: NA
Sub Pathway: NA
Inchikey: MJLXQSQYKZWZCB

Associated Genomic Regions

Region: rs4149056

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.216
Position:
21331549
SE (Ratio):
0.026
Effect Allele:
C
Z-score (Ratio):
-8.217
Reference Allele:
T
-log10(P):
-36.104
MAF:
0.156
Beta (Num):
-0.091
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.125
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 SLCO1A2 LST3

LLM Analysis

Numerator Metabolite Explanation:

Tyrosine Metabolism, Dopamine Metabolism.7[1], 8[2], 9[3], 10[4]

Denominator Metabolite Explanation:

Fatty Acid Beta-Oxidation, Carnitine Shuttle.11[1], 12[2], 13[3], 14[4]

Ratio Explanation:

The ratio likely reflects altered hepatic transport by SLCO1B1, which affects the clearance of diverse endogenous molecules like bilirubin, urate, and potentially these metabolites.5[1], 15[2], 16[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function impairs hepatic uptake of various substrates, including bilirubin and uric acid, leading to hyperbilirubinemia and gout.5[1], 15[2], 16[3] The ratio reflects this systemic transport defect which is a hallmark of phenotypes associated with SLCO1B1 variants.1[4], 4[5]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data