3-methoxytyrosine to eicosenoylcarnitine (c20:1)*

Numerator Metabolite

Structure of 3-methoxytyrosine
Metabolite Accession: GCST90200328
Name: 3-methoxytyrosine
Hmdb Id: HMDB0001434
Super Pathway: NA
Sub Pathway: NA
Inchikey: PFDUUKDQEHURQC

Denominator Metabolite

Structure of eicosenoylcarnitine (c20:1)*
Metabolite Accession: GCST90200148
Name: eicosenoylcarnitine (c20:1)*
Hmdb Id: HMDB0240746
Super Pathway: NA
Sub Pathway: NA
Inchikey: PVOQPLSKYNZHOT

Associated Genomic Regions

Region: rs67981690

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.219
Position:
21343886
SE (Ratio):
0.029
Effect Allele:
G
Z-score (Ratio):
-7.666
Reference Allele:
A
-log10(P):
-31.660
MAF:
0.132
Beta (Num):
-0.107
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
0.112
SE (Den):
0.022
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Catecholamine metabolism3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation5[1]

Ratio Explanation:

Decreased SLCO1B1 function may impair hepatic uptake of both 3-methoxytyrosine and eicosenoylcarnitine precursors or related compounds, altering their plasma ratio.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function is linked to altered bilirubin levels, a phenotype also associated with gout.1[1], 6[2], 7[3], 8[4] The gene's role in transporting various endogenous compounds could systemically impact metabolic balance, including pathways related to purine and lipid metabolism, influencing gout and related hematological traits.9[5]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data