1-palmitoyl-2-linoleoyl-gpc (16:0/18:2) to 1-(1-enyl-stearoyl)-gpe (p-18:0)*

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpc (16:0/18:2)
Metabolite Accession: GCST90200330
Name: 1-palmitoyl-2-linoleoyl-gpc (16:0/18:2)
Hmdb Id: HMDB0007973
Super Pathway: NA
Sub Pathway: NA
Inchikey: JLPULHDHAOZNQI

Denominator Metabolite

Metabolite Accession: GCST90199910
Name: 1-(1-enyl-stearoyl)-gpe (p-18:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.388
Position:
61588305
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
18.443
Reference Allele:
A
-log10(P):
-173.211
MAF:
0.345
Beta (Num):
0.276
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.112
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.5[1]

Denominator Metabolite Explanation:

Ether lipid metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio likely reflects the balance between glycerophospholipid and plasmalogen synthesis, which is influenced by the FADS-mediated availability of polyunsaturated fatty acids.1[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter polyunsaturated fatty acid metabolism, which is strongly associated with inflammatory conditions like asthma and IBD, and metabolic disorders including dyslipidemia, T2D, and cardiovascular disease.10[1], 11[2], 9[3], 12[4], 13[5] This ratio reflects the altered lipid landscape driven by FADS activity.

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data