1-palmitoyl-2-linoleoyl-gpc (16:0/18:2) to sphingomyelin (d18:2/24:1, d18:1/24:2)*

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpc (16:0/18:2)
Metabolite Accession: GCST90200330
Name: 1-palmitoyl-2-linoleoyl-gpc (16:0/18:2)
Hmdb Id: HMDB0007973
Super Pathway: NA
Sub Pathway: NA
Inchikey: JLPULHDHAOZNQI

Denominator Metabolite

Metabolite Accession: GCST90200040
Name: sphingomyelin (d18:2/24:1, d18:1/24:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.353
Position:
61588305
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
18.707
Reference Allele:
A
-log10(P):
-178.125
MAF:
0.345
Beta (Num):
0.276
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.077
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism5[1], 6[2]

Denominator Metabolite Explanation:

Sphingolipid metabolism7[1], 8[2]

Ratio Explanation:

The ratio reflects the balance between glycerophospholipid and sphingolipid synthesis, influenced by FADS1/FADS2 activity which alters the availability of polyunsaturated fatty acids for incorporation into these lipids.9[1], 10[2], 8[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter their desaturase activity, impacting the balance of polyunsaturated fatty acids.9[1], 11[2] This dysregulation is associated with altered lipid profiles and an increased risk for inflammatory conditions like asthma and inflammatory bowel disease.12[3], 13[4], 14[5], 15[6], 16[7], 17[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data