1-palmitoyl-2-linoleoyl-gpc (16:0/18:2) to 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpc (16:0/18:2)
Metabolite Accession: GCST90200330
Name: 1-palmitoyl-2-linoleoyl-gpc (16:0/18:2)
Hmdb Id: HMDB0007973
Super Pathway: NA
Sub Pathway: NA
Inchikey: JLPULHDHAOZNQI

Denominator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Metabolite Accession: GCST90200058
Name: 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Hmdb Id: HMDB0005779
Super Pathway: NA
Sub Pathway: NA
Inchikey: URPXXNCTXCOATD

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.564
Position:
61588305
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
25.384
Reference Allele:
A
-log10(P):
-325.641
MAF:
0.345
Beta (Num):
0.276
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.288
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.3[1]

Denominator Metabolite Explanation:

Ether lipid metabolism, Plasmalogen biosynthesis.4[1]

Ratio Explanation:

The ratio reflects FADS enzyme activity, contrasting a phosphatidylcholine containing linoleic acid (18:2) with a phosphatidylethanolamine plasmalogen containing arachidonic acid (20:4).1[1], 5[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in the FADS gene cluster, which includes FADS1 and FADS2, alters the activity of desaturase enzymes, thereby changing the balance of polyunsaturated fatty acids.1[1], 5[2], 6[3] This shift is reflected in the ratio and causally linked to altered cholesterol levels and hypercholesterolemia.7[4], 8[5], 9[6]

Phenotype Driver:

Metabolite-centric:1-palmitoyl-2-linoleoyl-gpc (16:0/18:2) to 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data