1-palmitoyl-2-linoleoyl-gpc (16:0/18:2) to 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpc (16:0/18:2)
Metabolite Accession: GCST90200330
Name: 1-palmitoyl-2-linoleoyl-gpc (16:0/18:2)
Hmdb Id: HMDB0007973
Super Pathway: NA
Sub Pathway: NA
Inchikey: JLPULHDHAOZNQI

Denominator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs173539

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.138
Position:
56988044
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
8.464
Reference Allele:
C
-log10(P):
-38.192
MAF:
0.334
Beta (Num):
0.090
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.048
SE (Den):
0.016
No CNV overlap
rQTL cluster:
26
Reaction Distance:
NA
Closest Genes:
CETP HERPUD1 NLRC5 SLC12A3 NUP93

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Phosphatidylinositol metabolism

Ratio Explanation:

The ratio reflects the balance of two major phospholipid classes, potentially modulated by CETP's role in transferring lipids between lipoproteins, thus altering membrane composition.1[1], 3[2], 5[3], 4[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

CETP gene variants influence lipid transfer, affecting the relative abundance of different phospholipid species. This altered lipid profile is associated with dyslipidemia and increased risk for atherosclerosis and myocardial infarction, key phenotypes observed.6[1], 7[2], 8[3], 9[4]

Phenotype Driver:

Gene-centric:CETP

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data