1-palmitoyl-2-linoleoyl-gpc (16:0/18:2) to 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpc (16:0/18:2)
Metabolite Accession: GCST90200330
Name: 1-palmitoyl-2-linoleoyl-gpc (16:0/18:2)
Hmdb Id: HMDB0007973
Super Pathway: NA
Sub Pathway: NA
Inchikey: JLPULHDHAOZNQI

Denominator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Associated Genomic Regions

Region: rs173539

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.142
Position:
56988044
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
8.292
Reference Allele:
C
-log10(P):
-36.734
MAF:
0.334
Beta (Num):
0.090
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.052
SE (Den):
0.016
No CNV overlap
rQTL cluster:
26
Reaction Distance:
NA
Closest Genes:
CETP HERPUD1 NLRC5 SLC12A3 NUP93

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleic acid metabolism.3[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Inositol phosphate metabolism.4[1]

Ratio Explanation:

The ratio of a specific phosphatidylcholine (PC) to phosphatidylinositol (PI) reflects lipoprotein composition, which is influenced by CETP-mediated lipid transfer between HDL and other lipoproteins.1[1], 5[2], 6[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

CETP's function in transferring lipids between lipoproteins alters circulating lipid profiles, including the relative abundance of different phospholipid species.1[1], 5[2] This genetically-driven change is a recognized risk factor for dyslipidemia and subsequent atherosclerotic cardiovascular diseases like myocardial infarction.6[3], 7[4], 8[5]

Phenotype Driver:

Gene-centric:CETP

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data