1-palmitoyl-2-linoleoyl-gpc (16:0/18:2) to cerotoylcarnitine (c26)*

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpc (16:0/18:2)
Metabolite Accession: GCST90200330
Name: 1-palmitoyl-2-linoleoyl-gpc (16:0/18:2)
Hmdb Id: HMDB0007973
Super Pathway: NA
Sub Pathway: NA
Inchikey: JLPULHDHAOZNQI

Denominator Metabolite

Structure of cerotoylcarnitine (c26)*
Metabolite Accession: GCST90200136
Name: cerotoylcarnitine (c26)*
Hmdb Id: HMDB0006347
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOCKWDDTAHPJSX

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.349
Position:
61569830
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
19.570
Reference Allele:
C
-log10(P):
-194.694
MAF:
0.341
Beta (Num):
0.276
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.073
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, Acylcarnitine metabolism6[1], 7[2]

Ratio Explanation:

The ratio reflects polyunsaturated fatty acid (PUFA) synthesis via FADS activity (numerator) relative to very-long-chain fatty acid oxidation (denominator), indicating lipid metabolism balance.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS gene variants alter desaturase activity, impacting levels of polyunsaturated fatty acids incorporated into phospholipids and influencing cholesterol levels and inflammatory responses seen in associated phenotypes like hypercholesterolemia and asthma.8[1], 2[2], 9[3], 10[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data