1-palmitoyl-2-oleoyl-gpe (16:0/18:1) to 1-stearoyl-gpc (18:0)

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Metabolite Accession: GCST90200331
Name: 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Hmdb Id: HMDB0005320
Super Pathway: NA
Sub Pathway: NA
Inchikey: FHQVHHIBKUMWTI

Denominator Metabolite

Structure of 1-stearoyl-gpc (18:0)
Metabolite Accession: GCST90199732
Name: 1-stearoyl-gpc (18:0)
Hmdb Id: HMDB0010384
Super Pathway: NA
Sub Pathway: NA
Inchikey: IHNKQIMGVNPMTC

Associated Genomic Regions

Region: rs174548

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.211
Position:
61571348
SE (Ratio):
0.023
Effect Allele:
G
Z-score (Ratio):
9.062
Reference Allele:
C
-log10(P):
-43.504
MAF:
0.309
Beta (Num):
0.098
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.113
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

This ratio contrasts a phosphatidylethanolamine (16:0/18:1) with a lysophosphatidylcholine (18:0), likely reflecting FADS1/FADS2 desaturase activity influencing fatty acid pool composition.1[1], 3[2], 4[3], 5[4]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1 variants alter desaturase activity, affecting the fatty acid pool.6[1], 7[2] This dysregulation of lipid metabolism contributes to associated phenotypes like hypercholesterolemia, cholelithiasis, and other observed lipidaemias by modifying lipid profiles and inflammatory responses.8[3], 9[4], 10[5], 11[6], 12[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data