1-palmitoyl-2-oleoyl-gpe (16:0/18:1) to 1-stearoyl-gpe (18:0)

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Metabolite Accession: GCST90200331
Name: 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Hmdb Id: HMDB0005320
Super Pathway: NA
Sub Pathway: NA
Inchikey: FHQVHHIBKUMWTI

Denominator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.188
Position:
61581764
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
10.435
Reference Allele:
T
-log10(P):
-57.021
MAF:
0.308
Beta (Num):
0.096
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
-0.092
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid biosynthesis, fatty acid metabolism.1[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Phospholipid biosynthesis, fatty acid metabolism.6[1], 7[2], 5[3]

Ratio Explanation:

The ratio reflects the balance of fatty acids incorporated into phosphatidylethanolamines, influenced by FADS1 activity which alters the availability of different fatty acid species.8[1], 9[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1 variants alter desaturase activity, affecting the fatty acid pool for phospholipid synthesis. This change in lipid composition is linked to cholelithiasis (gallstones), dyslipidemia, and inflammatory conditions like asthma and sinusitis, likely by modifying cholesterol metabolism and inflammatory pathways.10[1], 11[2]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data